A mobile robotic process chemist

Emma J. Brass

doi:10.1039/D5DD00563A

2026-03-02

Emma J. Brass

Satheeshkumar Veeramani

DOI：10.1039/D5DD00563A

原文链接

原文求助

摘要

En 中文

工艺化学为新先导分子创造可扩展的合成路线，是制药和农化开发周期中至关重要但劳动密集的阶段。我们构建了一个自动化工艺化学平台，用于解决后期的工艺开发问题。该模块化工作流程整合了行业标准工具和定制设备，以实现过程规模合成、后处理和分析。一台多功能移动机器人在自动化合成反应器与超高效液相色谱-质谱联用仪（UHPLC-MS）之间工作，用于产品分析，并在批次间清洗反应器。该机器人的仿人操作能力使其能够与经过最小化重新设计的设备对接，这些设备可与人工作研究人员共享。反应收率和纯度与人类化学师的表现相当。全天候、连续实验的计时结果表明，在工业环境中，该机器人操作多个反应器的每周反应产出量可能是人类工艺化学师的12倍。

Keyword:

Process chemistry

Automated synthesis

Mobile robot

Reaction optimization

UHPLC-MS analysis

期刊

Digital Discovery

IF:

5.6

论文数:

997

被引数:

1.7K

机构

university of liverpool

学者数:

3.4K

论文数: 1.8K

被引数: 0

引用论文

Autonomous, multiproperty-driven molecular discovery: From predictions to measurements and back 自主，多属性驱动的分子发现: 从预测到测量再到

Science

IF0

2023-12-22

OAAI

Brent A. Koscher; Richard B. Canty; Matthew A. McDonald; Kevin P. Greenman; Charles J. McGill; Camille L. Bilodeau; Wengong Jin; Haoyang Wu; Florence H. Vermeire; Brooke Jin; Travis Hart; Timothy Kulesza; Shih-Cheng Li; Tommi S. Jaakkola; Regina Barzilay; Rafael Gómez-Bombarelli; William H. Green; Klavs F. Jensen

A mobile robotic chemist 移动机器人化学家

NATURE

IF48.5

2020-07-08

766

PREAI

Burger, Benjamin; Maffettone, Phillip M.; Gusev, Vladimir V.; Aitchison, Catherine M.; Bai, Yang; Wang, Xiaoyan; Li, Xiaobo; Alston, Ben M.; Li, Buyi; Clowes, Rob; Rankin, Nicola; Harris, Brandon; Sprick, Reiner Sebastian; Cooper, Andrew I.

Uniting laboratory automation, DoE data, and modeling techniques to accelerate chemical process development

REACTION CHEMISTRY & ENGINEERING

IF3.1

2019-01-01

PREAI

Rosso, Victor; Albrecht, Jacob; Roberts, Frederick; Janey, Jacob M.

Accelerating reaction optimization through data-rich experimentation and machine-assisted process development

REACTION CHEMISTRY & ENGINEERING

IF3.1

2024-01-01

PREAI

McMullen, Jonathan P.; Jurica, Jon A.

Leveraging GPT-4 to transform chemistry from paper to practice

DIGITAL DISCOVERY

IF5.6

2024-01-01

OAAI

Zhang, Wenyu; Guy, Mason A.; Yang, Jerrica; Hao, Lucy; Liu, Junliang; Hawkins, Joel M.; Mustakis, Jason; Monfette, Sebastien; Hein, Jason E.

Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2021-10-25

PREAI

Ashworth, Ian W.; Frodsham, Lianne; Moore, Peter; Ronson, Thomas O.

Synthesis of many different types of organic small molecules using one automated process 使用一个自动化过程合成许多不同类型的有机小分子

Science

IF0

2015-03-13

OAAI

Junqi Li; Steven G. Ballmer; Eric P. Gillis; Seiko Fujii; Michael J. Schmidt; Andrea M. E. Palazzolo; Jonathan W. Lehmann; Greg F. Morehouse; Martin D. Burke

A robotic platform for flow synthesis of organic compounds informed by AI planning 由AI计划提供的用于有机化合物流动合成的机器人平台

Science

IF0

2019-08-09

PREAI

Connor W. Coley; Dale A. Thomas; Justin A. M. Lummiss; Jonathan N. Jaworski; Christopher P. Breen; Victor Schultz; Travis Hart; Joshua S. Fishman; Luke Rogers; Hanyu Gao; Robert W. Hicklin; Pieter P. Plehiers; Joshua Byington; John S. Piotti; William H. Green; A. John Hart; Timothy F. Jamison; Klavs F. Jensen

The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2017-11-27

242

PREAI

Krska, Shane W.; DiRocco, Daniel A.; Dreher, Spencer D.; Shevlin, Michael

An all-round AI-Chemist with a scientific mind 具有科学头脑的全面AI化学家

NATIONAL SCIENCE REVIEW

IF17.1

2022-09-08

OAAI

Zhu, Qing; Zhang, Fei; Huang, Yan; Xiao, Hengyu; Zhao, LuYuan; Zhang, XuChun; Song, Tao; Tang, XinSheng; Li, Xiang; He, Guo; Chong, BaoChen; Zhou, JunYi; Zhang, YiHan; Zhang, Baicheng; Cao, JiaQi; Luo, Man; Wang, Song; Ye, GuiLin; Zhang, WanJun; Chen, Xin; Cong, Shuang; Zhou, Donglai; Li, Huirong; Li, Jialei; Zou, Gang; Shang, WeiWei; Jiang, Jun; Luo, Yi

查看更多内容