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A physicochemical perspective on cellular ageing
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DOI：10.1016/j.tibs.2023.08.007.png)
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摘要
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Cellular ageing described at the molecular level is a multifactorial process that leads to a spectrum of ageing trajectories. There has been recent discussion about whether a decline in physicochemical homeostasis causes aberrant phase transitions, which are a driver of ageing. Indeed, the function of all biological macromolecules, regardless of their participation in biomolecular condensates, depends on parameters such as pH, crowding, and redox state. We expand on the physicochemical homeostasis hypothesis and summarise recent evidence that the intracellular milieu influences molecular processes involved in ageing.
Keyword:
LIFE-SPAN
SACCHAROMYCES-CEREVISIAE
STRESS RESISTANCE
PROTON PUMPS
YEAST
CELLS
VACUOLAR
CYTOPLASM
SIZE
ATP
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11
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