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A segmental genomic duplication generates a functional intron
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DOI：10.1038/ncomms1461.png)
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摘要
En 中文
An intron is an extended genomic feature whose function requires multiple constrained positions-donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splicing enhancers-that may be distributed over hundreds or thousands of nucleotides. New introns are therefore unlikely to emerge by incremental accumulation of functional sub-elements. Here we demonstrate that a functional intron can be created de novo in a single step by a segmental genomic duplication. This experiment recapitulates in vivo the birth of an intron that arose in the ancestral jawed vertebrate lineage nearly half-a-billion years ago.
Keyword:
RETICULUM CA2+ ATPASE
BRODY-DISEASE
SPLICEOSOMAL INTRONS
MUTATION
SERCA1
GENE
CONSEQUENCES
MECHANISMS
EVOLUTION
BIRTH
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15.7
论文数:
9.4W
被引数:
91.2W
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Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: An animal model of human Brody disease.png)
GENOMICS
GENOMICSIF3
PREAI
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