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Advanced reactivity-based sequencing methods for mRNA epitranscriptome profiling
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DOI：10.1039/d4cb00215f.png)
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摘要
En 中文
Currently, over 170 chemical modifications identified in RNA introduce an additional regulatory attribute to gene expression, known as the epitranscriptome. The development of detection methods to pinpoint the location and quantify these dynamic and reversible modifications has significantly expanded our understanding of their roles. This review goes deep into the latest progress in enzyme- and chemical-assisted sequencing methods, highlighting the opportunities presented by these reactivity-based techniques for detailed characterization of RNA modifications. Our survey provides a deeper understanding of the function and biological roles of RNA modification.
Keyword:
PHOTO-CROSS-LINKING
18S RIBOSOMAL-RNA
BIOLOGICAL FUNCTIONS
NUCLEAR-RNA
M(6)A RNA
N-1-METHYLADENOSINE METHYLOME
STRUCTURAL BASIS
HIGH-THROUGHPUT
PSEUDOURIDINE
METHYLATION
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3.1
论文数:
697
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1.6K
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