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摘要
En 中文
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes - the waste-disposal units of the cell - typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?.
Keyword:
MHC CLASS-I
NEWLY SYNTHESIZED PROTEINS
20S PROTEASOME
INTERFERON-GAMMA
CTL EPITOPE
MULTICATALYTIC PROTEINASE
RAPID DEGRADATION
BETA-SUBUNITS
ACTIVE-SITE
PEPTIDE
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N
IF:
90.2
论文数:
4.1K
被引数:
7.3W
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引用论文
Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein小鼠20s蛋白酶体复合物中定义的活性位点的失活增强了鼠巨细胞病毒蛋白的主要组织相容性复合物I类抗原呈递.png)
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收藏Analysis of mammalian 20S proteasome biogenesis: The maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.png)
EMBO JOURNAL
EMBO JOURNALIF8.3
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