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Antioxidant and Anti-Inflammatory Potential of Kimchi-Derived Lactic Acid Bacteria Strains
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DOI：10.1155/jfbc/1356304.png)
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Abstract
En 中文
Lactic acid bacteria (LAB) isolated from kimchi are known to possess various functional properties, contributing to the health-beneficial effects of fermented products. Although the antioxidant activity of LAB has been previously reported, relatively few studies have focused on the antioxidant activity of LAB-derived cell-free supernatants (LAB CFS). We investigated the potential of LAB as inflammation-modulating kimchi starters and evaluated their inflammation-modulating activities in macrophages. We evaluated the antioxidant activities of LAB CFS using total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays before performing a cell-based assay. We first confirmed cell viability, and then screened macrophages exposed to lipopolysaccharide (LPS) based on nitric oxide (NO) production. Selected LAB were further evaluated for their effects on NO, reactive oxygen species (ROS), and the expression of inflammatory genes and proteins. Most LAB CFS exhibited antioxidant activity. Four LAB CFS (Latilactobacillus curvatus-W1, Lactiplantibacillus plantarum-W1, Lactiplantibacillus plantarum-W2, and Levilactobacillus brevis-W2) were selected for their potent inhibitory effects on NO production at concentrations of 5% and 10%, without exhibiting cytotoxicity. These LAB CFS significantly reduced NO and ROS levels and the proinflammatory gene and protein expression in macrophages. Among them, L. brevis-W2 effectively inhibited the inflammatory response in RAW264.7 cells. Overall, the LAB CFS isolated from kimchi showed significant antioxidant and inflammation-modulating activities. The results indicate that certain LAB CFS, especially L. brevis-W2, could serve as functional ingredients or effective starters for developing fermented foods to improve health benefits.
Keywords:
anti-inflammation
cell-free supernatant
lactic acid bacteria
nitric oxide
RAW264.7 cells
reactive oxygen species
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