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Apicomplexa micropore: history, function, and formation

delete2024-05-01
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PRE
AI
J
Jiong Yang
龙
龙少军 (Shaojun Long)
G
Geoff Hide
Z
Zhao‐Rong Lun
赖德华 封面图
赖德华 (De‐Hua Lai) *
DOI:10.1016/j.pt.2024.03.008delete
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摘要

摘要

En 中文
The micropore, a mysterious structure found in apicomplexan species, was recently shown to be essential for nutrient acquisition in Plasmodium falciparum and Toxoplasma gondii . However, the differences between the micropores of these two parasites questions the nature of a general apicomplexan micropore structure and whether the formation process model from Plasmodium can be applied to other apicomplexans. We analyzed the literature on different apicomplexan micropores and found that T. gondii probably harbors a more representative micropore type than the more widely studied ones in Plasmodium . Using recent knowledge of the Kelch 13 (K13) protein interactome and gene depletion phenotypes in the T. gondii micropore, we propose a model of micropore formation, thus enriching our wider understanding of micropore protein function.
Keyword:
GEHYRA VARIEGATA DUMERIL
ARTEMISININ RESISTANCE
PROTEIN UBIQUITINATION
SALIVARY-GLANDS
FINE-STRUCTURE
LIFE-CYCLE
ULTRASTRUCTURE
PLASMODIUM
HEMOGLOBIN
ENDOCYTOSIS

期刊

Trends in Parasitology 封面图
Trends in Parasitology
IF:
6.6
论文数:
3.1K
被引数:
8.2K

机构

S
Sun Yat Sen University
学者数:
9.9W
论文数: 7.2W
被引数: 95
U
University of Salford
学者数:
2.4K
论文数: 2.5K
被引数: 2.9K
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