Arresting metastasis within the microcirculation

doi:10.1007/s10585-021-10109-8

2021-07-09

Angelos Varotsos Vrynas

Julia Perea Paizal

Chris Bakal

Sam H. Au *

DOI：10.1007/s10585-021-10109-8

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摘要

En 中文

The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.

Keyword:

Circulating tumour cells

Metastasis

Cancer

Biomechanics

Microvasculature

Immune cells

Platelets

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期刊

Clinical and Experimental Metastasis

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3.2

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2.4K

被引数:

3.4K

机构

Imperial College London

学者数:

8.3W

论文数: 7.3W

被引数: 11.1W

Royal Marsden NHS Foundation Trust

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1.1W

论文数: 7.1K

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