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Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC空间单细胞蛋白质分型揭示转移性非小细胞肺癌复杂肿瘤微环境中的免疫治疗抵抗特征
Isomoto, Kohsuke; Haratani, Koji; Tsujikawa, Takahiro; Tomida, Shuta; Makutani, Yusuke; Takeda, Masayuki; Yonesaka, Kimio; Tanaka, Kaoru; Iwasa, Tsutomu; Sakai, Kazuko; Nishio, Kazuto; Ito, Akihiko; Nakagawa, Kazuhiko; Hayashi, Hidetoshi.png)
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收藏 Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model抑制鞘脂合成可改善癌症恶病质模型中的机体消耗Morigny, Pauline; Ji, Honglei; Cussonneau, Laura; Zorzato, Sabrina; Kwon, Yun; Riols, Fabien; Kaltenecker, Doris; Maier, Alisa; Karthikaisamy, Vignesh; Corra, Samantha; Krauss, Tanja; Seeliger, Claudine; Gillani, Syed Qaaifah; Tissink, Joel J.; Lacas-Gervais, Sandra; Samanci, Tuna Felix; Maida, Adriano; Terron-Exposito, Raul; Trinca, Angela; von Toerne, Christine; Nogara, Leonardo; Claussnitzer, Melina; Prokopchuk, Olga; Bachmann, Jeannine; Diaz, Mauricio Berriel; Bindels, Laure B.; Kuda, Ondrej; Hauner, Hans; Haid, Mark; Herzig, Stephan; Viscomi, Carlo Fiore; Gilleron, Jerome; Zeigerer, Anja; Blaauw, Bert; Rohm, Maria 分享 收藏 Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamicsRPGR缺失通过影响F-肌动蛋白动力学破坏动力纤毛并导致原发性纤毛运动障碍Wu, Yang; Tavares, Erika; Liang, Binrun; Wee, Wallace B.; Mennella, Vito; Feng, Han-Chao; Cao, Jiaying; Wong, Pui Yee; Zheng, Jiayi; He, Mu; Stephenson, Kirk A. J.; Hochma, Liran Hanan; Li, Janice Min; Chen, Nan-Peng; Dell, Sharon D.; Heon, Elise; Liu, Zhen 分享 收藏 Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis雌激素受体β缺乏通过代谢重编程诱导的巨噬细胞焦亡增加对脓毒症的易感性Zhu, Yanrong; Li, Gang; Guo, Yilei; He, Yue; Zhang, Wanyi; Gao, Lei; Zhang, Jing; Guo, Pengxiang; Lin, Haochang; Zhang, Wenjie; Wei, Zhifeng; Xia, Yufeng; Dai, Yue 分享 收藏 Modulation of WNT and FGF18 enhances yield and subtype identity of hPSC-derived midbrain dopamine neuronsWNT和FGF18的调控增强人源多能干细胞来源的中脑多巴胺神经元的产量和亚型特性Kim, Tae Wan; Piao, Jinghua; Bocchi, Vittoria D.; Koo, So Yeon; Choi, Se Joon; Chaudhry, Fayzan; Yang, Donghe; Cho, Hyein S.; Hergenreder, Emiliano; Perera, Lucia Ruiz; Joshi, Subhashini; Abou Mrad, Zaki; Claros, Nidia; Donohue, Shkurte Ademi; Im, Yeong Eun; Jeong, Hyo Jae; Frank, Anika K.; Walsh, Ryan M.; Mosharov, Eugene, V; Betel, Doron; Tabar, Viviane; Studer, Lorenz 分享 收藏 In vivo CRISPR screens identify CBX4 as an epigenetic regulator for cancer immunotherapy体内CRISPR筛选鉴定CBX4为癌症免疫治疗的表观遗传调控因子Ma, Zhibo; Jia, Wenlong; Zhou, Xi; Liu, Jing; Li, Qingwen; Chang, Ruizhi; Shiqi, Gu; Yuan, Naonao; Chen, Zhishui; Lan, Peixiang 分享 收藏 Genome-wide CRISPR screen identifies a cytokineenhancer circuit driving HIF-2α activation in renal cancer全基因组CRISPR筛选鉴定出驱动肾癌中HIF-2α活化的细胞因子增强子回路Fang, Jun; Simon, Jeremy M.; Wang, Tao; Gao, Yunpeng; Bi, Xianju; Hu, Lianxin; Liao, Chengheng; Zhang, Cheng; Adachi, Yayoi; Zhou, Jin; Liu, Hongyi; Liang, Qian; Nathan, James A.; Mani, Ram; Brugarolas, James; Zhang, Qing 分享 收藏 Wdr26 insufficiency causes Skraban-Deardorff syndrome-like neurodevelopmental deficits in miceWdr26缺乏导致小鼠出现斯克拉班-迪亚德夫综合征样神经发育缺陷Xu, Xingyun; Zhou, Yaohui; Xu, Shiyao; Zhou, Hongjie; Lin, Xuexia; Luo, Yuhao; Xu, Yu; Miao, Zhigang; Ge, Wei; Yang, Hao; Xu, Xingshun 分享 收藏 Targeting RANKL-independent osteoclastogenesis overcomes denosumab resistance in models of ER+ breast cancer bone metastasis靶向RANKL非依赖性破骨细胞生成克服了ER+乳腺癌骨转移模型中的地诺单抗耐药性Lin, Qun; Luo, Jinpeng; Duan, Zhuxi; Luo, Jieer; Zhang, Wei; Xia, Yuan; Zeng, Yinduo; Fang, Xiaolin; Liang, Jiahui; Chen, Jiayi; Lin, Qianchong; Quan, Yilin; Hu, Ruiyu; Liu, Hongcai; Liu, Qiang; Li, Jun; Gong, Chang 分享 收藏 Cilia-independent gas-liquid transport, athird mechanism mediating airway mucus clearance非纤毛依赖的气-液传输：调节气道黏液清除的第三种机制Shenoy, Siddharth K.; Gutay, Mark; Brown, Ian; Rogers, Troy D.; Banner, Kane; Olegario, Nico; Griffin, Nicholas; Goodell, Henry P.; Yoder, Bryan; Lalush, David S.; Edwards, David A.; Boucher, Richard C.; Grubb, Barbara R.; Button, Brian 分享 收藏 Phase II trial of sodium phenylbutyrate and taurursodiol in Wolfram syndrome二氢苯丁酸钠和Taurursodiol在沃尔夫综合征中的II期临床试验Urano, Fumihiko; Marshall, Bess A.; Hurst, Stacy; Robichaux-Viehoever, Amy; Ahmadi, Saumel; Hershey, Tamara; Van Stavern, Gregory; Bravo, Paulina Cruz; Carson, Jennifer Powers; Pesko, John; Fox, Kelly; Erpelding, Nathalie; Bedrosian, Camille L. 分享 收藏 Metastatic tropism of molecularly defined clear-cell renal cell carcinoma clusters分子定义的透明细胞肾细胞癌亚群转移趋向性Haddad, Gaelle; Guo, Junyu; Xi, Yin; Albayrak, Emin; Huseni, Mahrukh; Hamidi, Habib; Banchereau, Romain; Kadel, Edward; Dubey, Sarita; Carter, Corey; Kapur, Payal; Brugarolas, James; Pedrosa, Ivan 分享 收藏 Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models反复发生的逆行月经通过神经炎症增强子宫内膜异位症模型中的中枢敏化Harvey, Madeleine E.; Shi, Mingxin; Oh, Yeongseok; Page, Taylor M.; Mitchell, Debra A.; Luo, Addie; Slayden, Ov D.; MacLean, James A.; Sharma, Anjali; Hayashi, Kanako 分享 收藏 
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