Asbestos Disease Initiation

Alisa DeStefano

doi:10.1007/s11538-026-01605-7

2026-02-19

Alisa DeStefano *

Clyde F. Martin

Dorothy Wallace

DOI：10.1007/s11538-026-01605-7

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摘要

En 中文

基于伤口愈合和石棉转运的先验模型，开发了一种用于石棉相关斑块沉积和间皮瘤的疾病启动与进展模型。该模型包含巨噬细胞极化、免疫系统反应等短期过程，并将时间框架扩展至可检测疾病的范围。模型结果在生物学合理范围内。癌症发展和斑块沉积被证明取决于总暴露量（强度*持续时间）。斑块沉积对许多系统性参数敏感，表明可开发检测高风险个体的方法。肿瘤发展仅对描述暴露和T细胞水平的少数参数敏感，提示免疫系统干预的潜力。

Keyword:

Asbestos exposure

Mesothelioma

Pleural plaque

Lung fibrosis

Asbestosis

期刊

Bulletin of Mathematical Biology

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2.2

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122

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5.7K

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Texas Tech University System

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1.5W

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College of the Holy Cross

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366

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texas tech university

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1.4K

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被引数: 0

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