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Building mitotic chromosomes

delete2011-02-01
delete40
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OA
AI
S
Shinya Ohta
L
Laura Wood
J
Jimi Wills
J
Juri Rappsilber
W
William C. Earnshaw *
DOI：10.1016/j.ceb.2010.09.009delete
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摘要

摘要

En 中文
Mitotic chromosomes are the iconic structures into which the genome is packaged to ensure its accurate segregation during mitosis. Although they have appeared on countless journal cover illustrations, there remains no consensus on how the chromatin fiber is packaged during mitosis. In fact, work in recent years has both added to existing controversies and sparked new ones. By contrast, there has been very significant progress in determining the protein composition of isolated mitotic chromosomes. Here, we discuss recent studies of chromosome organization and provide an in depth description of the latest proteomics studies, which have at last provided us with a definitive proteome for vertebrate chromosomes.
Keyword:
KINETOCHORE-MICROTUBULE ATTACHMENT
DNA TOPOISOMERASE-II
MOLECULAR ARCHITECTURE
CENTROMERE ORGANIZATION
PROTEOME ANALYSIS
CELL-DIVISION
CROSS-LINKING
SMC PROTEINS
CENP-A
CONDENSIN
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期刊

Current Opinion in Cell Biology 封面图
Current Opinion in Cell Biology
IF:
4.3
论文数:
3.2K
被引数:
1.2W

机构

U
University of Edinburgh
学者数:
5.2W
论文数: 4.6W
被引数: 71
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