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CDT1, a licensing factor that limits rereplication
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DOI：10.1016/j.molcel.2022.11.019.png)
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摘要
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Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)(1) reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
Keyword:
DNA-REPLICATION
GEMININ
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期刊
IF:
16.6
论文数:
1.0W
被引数:
8.5W
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引用论文
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.png)
MOLECULAR CELLOAAI
MOLECULAR CELLIF16.6
OAAI分享收藏Distinct and sequential re-replication barriers ensure precise genome duplicationPLOS GENETICSOAAI
PLOS GENETICSIF3.7
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