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Cell Decoder: decoding cell identity with multi-scale explainable deep learning

delete2025-10-22
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OA
AI
朱军 封面图
朱军 (Jun Zhu)
Z
Zeyang Zhang
Y
Yujia Xiang
B
Beini Xie
X
Xinwen Dong
L
Linhai Xie
P
Peijie Zhou
R
Rongyan Yao
X
Xiaowen Wang
L
Li Yang
F
Fuchu He *
Wenwu Zhu 封面图
Wenwu Zhu (Wenwu Zhu)
Z
Ziwei Zhang
C
Cheng Chang
DOI:10.1186/s13059-025-03832-ydelete
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摘要

摘要

En 中文
细胞是生命的基本单位,理解其多样性和功能需要详细的表征。单细胞组学数据的兴起使得这一点成为可能,但当前深度学习方法缺乏多尺度可解释性。我们介绍了Cell Decoder模型,该模型整合了生物先验知识,以提供细胞的多尺度表征。通过使用自动化机器学习和事后分析,Cell Decoder解码细胞身份,并优于现有方法。它提供多视角可解释性,并促进数据整合。应用于人类骨骼和鼠胚数据时,Cell Decoder揭示了细胞身份的多尺度异质性,为加深我们对细胞多样性的理解提供了一个强大的框架。
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期刊

G
Genome Biology
IF:
9.4
论文数:
6.4K
被引数:
7.3W

机构

T
tsinghua university
学者数:
11.9W
论文数: 10.0W
被引数: 137
P
peking university
学者数:
11.9W
论文数: 8.7W
被引数: 146
引用论文

引用论文

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