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CellSAM: a foundation model for cell segmentation

delete2025-12-08
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OA
AI
M
Markus Marks
U
Uriah Israel
R
Rohit Dilip
Q
Qilin Li
C
Changhua Yu
E
Emily Laubscher
A
Ahamed Iqbal
E
Elora Pradhan
A
Ada Ates
M
Martin Abt
C
Caitlin Brown
E
Edward Pao
S
Shenyi Li
A
Alexander Pearson-Goulart
P
Pietro Perona
G
Georgia Gkioxari
R
Ross Barnowski
Y
Yisong Yue
D
David Van Valen *
DOI:10.1038/s41592-025-02879-wdelete
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摘要

摘要

En 中文
细胞是生物组织的基本单元,而在成像数据中识别它们——即细胞分割——是各种细胞成像实验中的关键任务。尽管深度学习方法在该问题上取得了显著进展,但大多数模型都是专业模型,仅适用于特定领域,无法跨领域应用或难以适应大量数据。在此,我们提出CellSAM,一种适用于细胞分割的通用模型,能够泛化至多样化的细胞成像数据。CellSAM在Segment Anything Model(SAM)的基础上构建,通过开发一种用于掩码生成的提示工程方法。我们训练了一个目标检测器CellFinder,用于自动检测细胞并提示SAM生成分割结果。我们证明,这种方法使单一模型能够实现哺乳动物细胞、酵母和细菌图像分割的人类水平性能,这些图像通过多种成像模态采集。我们展示CellSAM具有强大的零样本性能,并可通过少量示例通过少样本学习得到改进。此外,我们演示了CellSAM如何应用于多样化的生物图像分析工作流程。CellSAM的部署版本可在 https://cellsam.deepcell.org/ 获取。CellSAM使用目标检测器CellFinder检测细胞,并提示Segment Anything Model(SAM)生成分割结果。这一通用模型在涵盖哺乳动物细胞、酵母和细菌的多种生物成像数据上实现了人类水平的性能。
Keyword:
Cell segmentation
Deep learning
Universal model
CellFinder
Segment Anything Model
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Nature Methods
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CALTECH
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