.png){kind=icon}
返回
Cellular reprogramming through mitogen-activated protein kinases
.png){kind=icon}
OA
AI
DOI：10.3389/fpls.2015.00940.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Mitogen-activated protein kinase (MAPK) cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes. While some progress in the identification of MAPK substrates has been made in plants, the knowledge on the spectrum of substrates and their mechanistic action is still fragmentary. In this focused review, we discuss the biological implications of the data in our original paper (Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana; Frontiers in Plant Science 5: 554) in the context of related research. In our work, we mimicked in vivo activation of two stress-activated MAPKs, MPK3 and MPK6, through transgenic manipulation of Arabidopsis thaliana and used phosphoproteomics analysis to identify potential novel MAPK substrates. Here, we plotted the identified putative MAPK substrates (and downstream phosphoproteins) as a global protein clustering network. Based on a highly stringent selection confidence level, the core networks highlighted a MAPK-induced cellular reprogramming at multiple levels of gene and protein expression including transcriptional, post-transcriptional, translational, post-translational (such as protein modification, folding, and degradation) steps, and also protein re-compartmentalization. Additionally, the increase in putative substrates/phosphoproteins of energy metabolism and various secondary metabolite biosynthesis pathways coincides with the observed accumulation of defense antimicrobial substances as detected by metabolome analysis. Furthermore, detection of protein networks in phospholipid or redox elements suggests activation of downstream signaling events. Taken in context with other studies, MAPKs are key regulators that reprogram cellular events to orchestrate defense signaling in eukaryotes.
Keyword:
MAPK substrates
phosphorylation
phosphoproteome
metabolome
chemical defense
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.8
论文数:
3.5W
被引数:
14.7W
机构
引用论文
RNA granules: post-transcriptional and epigenetic modulators of gene expressionRNA颗粒: 基因表达的转录后和表观遗传调节剂
PREAI
分享收藏Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis.png)
PLANT CELLOAAI
PLANT CELLIF11.6
OAAI分享收藏Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleusEMBO JOURNALOAAI
EMBO JOURNALIF8.3
OAAI分享收藏Mitogen-Activated Protein Kinase Cascades and Ethylene: Signaling, Biosynthesis, or Both?PLANT PHYSIOLOGYOAAI
PLANT PHYSIOLOGYIF6.9
OAAI分享收藏RPN1a, a 26S proteasome subunit, is required for innate immunity in ArabidopsisPLANT JOURNAL
PLANT JOURNALIF5.7
PREAI
分享收藏
查看更多内容