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CholesteroNitrones for Stroke
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DOI：10.1021/acs.jmedchem.5b00755.png)
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摘要
En 中文
This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.
Keyword:
CEREBRAL-ISCHEMIA
BRAIN-INJURY
NITRONES
NXY-059
NEUROPROTECTION
ANTIOXIDANTS
THERAPEUTICS
BARRIER
AGENTS
PBN
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期刊
IF:
6.8
论文数:
2.7W
被引数:
10.2W
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Crossing the barrier:: oxysterols as cholesterol transporters and metabolic modulators in the brain
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