Chromatin accessibility dynamics during cell fate reprogramming

Dongwei Li

doi:10.15252/embr.202051644

2021-01-22

DOI：10.15252/embr.202051644

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摘要

En 中文

Genome architecture and chromatin dynamics govern the fate and identify of a cell. Recent advances in mapping chromatin landscapes offer valuable tools for the acquisition of accurate information regarding chromatin dynamics. Here we discuss recent findings linking chromatin dynamics to cell fate control. Specifically, chromatin undergoes a binary off/on switch during iPSC reprogramming, closing and opening loci occupied by somatic and pluripotency transcription factors, respectively. This logic of a binary off/on switch may also be operational in cell fate control during normal development and implies that further approaches could potentially be developed to direct cell fate changes both in vitro and in vivo.

Keyword:

chromatin dynamics

reprogramming

stem cell

期刊

EMBO Reports

IF:

6.2

论文数:

6.4K

被引数:

2.1W

机构

guangzhou institute of biomedicine & health, cas

学者数:

1.1K

论文数: 685

被引数: 1

chinese academy of sciences

学者数:

56.7W

论文数: 45.0W

被引数: 704

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