Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

doi:10.1038/nbt1199

2006-03-12

209

PRE

DOI：10.1038/nbt1199

原文求助

摘要

En 中文

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

Keyword:

DRUG-DELIVERY

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期刊

Nature Biotechnology

IF:

41.7

论文数:

1.2W

被引数:

10.1W

机构

暂无机构信息

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