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Complement - tapping into new sites and effector systems
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DOI：10.1038/nri3761.png)
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Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.
Keyword:
T-CELL HOMEOSTASIS
C5AR EXPRESSION
3RD COMPONENT
5TH COMPONENT
STEM-CELLS
HUMAN C3
ACTIVATION
RECEPTOR
INDUCTION
REGULATOR
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60.9
论文数:
4.2K
被引数:
6.5W
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Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells通过C5a受体和C3a受体的信号减弱小鼠天然调节性T细胞的功能
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