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Complex I function in mitochondrial supercomplexes
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DOI：10.1016/j.bbabio.2016.01.013.png)
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摘要
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This review discusses the functional properties of mitochondria! Complex I originating from its presence in an assembled form as a supercomplex comprising Complex III and Complex IV in stoichiometric ratios. In particular several lines of evidence are presented favouring the concept that electron transfer from Complex I to Complex HI is operated by channelling of electrons through Coenzyme Q molecules bound to the supercomplex, in contrast with the hypothesis that the transfer of reducing equivalents from Complex I to Complex III occurs via random diffusion of the Coenzyme Q molecules in the lipid bilayer. Furthermore, another property provided by the supercomplex assembly is the control of generation of reactive oxygen species by Complex I. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt. (C) 2016 Elsevier B.V. All rights reserved.
Keyword:
Mitochondria
Complex I (NADH:ubiquinone oxidoreductase)
Supercomplex
Channelling
ROS
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B
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2.7
论文数:
6.1K
被引数:
1.1W
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