Contract to kill: GNAS mutation

Pratima Raut

doi:10.1186/s12943-025-02247-4

2025-03-07

Pratima Raut

Poompozhil Mathivanan

Surinder K. Batra

Moorthy P. Ponnusamy *

DOI：10.1186/s12943-025-02247-4

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摘要

En 中文

Gs alpha编码基因GNAS外显子的突变，作为广为人知的gsp癌基因，是所有参与致癌作用的三聚体G蛋白中最常见的突变。GNAS R201是最常发生突变的位点，其次是Q227，这些突变在各种新生物和癌症中广泛存在，例如IPMN、垂体、甲状腺、阑尾、结直肠等。本综述强调了gsp癌基因及其在维持GNAS突变持续依赖性方面的重要意义。重点介绍了近期研究阐明的机制细节，这些研究为致癌性GNAS对肿瘤形成、进展和维持的深远影响提供了有力证据。我们利用了将Gs alpha作为疫苗治疗理想新抗原候选物的发现，并探索了针对等位基因特异性抑制剂和基于环状肽的小分子G蛋白抑制剂的疗法，以直接靶向致癌性GNAS的潜力。此外，还讨论了替代性治疗方法和以患者为中心的研究，以减轻GNAS突变的影响。重点突出了旨在解决靶向GNAS激活突变方法中固有挑战的新型研究和策略，以及可能的进一步研究方向。本综述旨在深入探讨GNAS的致癌潜能、GNAS驱动的肿瘤和癌症的基因组学与生物学特征，以及针对这些疾病的治疗策略。

Keyword:

GNAS

Gs alpha

GNAS R201

Mutation

Tumor

Neoplasm

期刊

Molecular Cancer

IF:

33.9

论文数:

4.0K

被引数:

4.2W

机构

Univ Nebraska Med Ctr

学者数:

640

论文数: 874

被引数: 53

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