CTRP10 is required for optimal motor function

Fangluo Chen

doi:10.1016/j.jbc.2026.111420

2026-03-31

Fangluo Chen

Muzna Saqib

Chantelle E. Terrillion

DOI：10.1016/j.jbc.2026.111420

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摘要

En 中文

CTRP10，又称C1QL2，是C1q家族的一种分泌蛋白。在中枢神经系统中，CTRP10主要由神经元和少突胶质细胞表达。脑内CTRP10表达的变化与成瘾、抑郁和精神障碍相关。CTRP10还作为前丘脑核复合体中兴奋性神经元以及控制本体感觉和精细运动技能的神经元的特异性分子标记。CTRP10是否对神经系统控制行为是必需的尚不清楚。在此，我们确定CTRP10缺乏是否以及如何对小鼠行为产生不利影响。缺乏CTRP10的组成性敲除（KO）小鼠具有正常的探索行为、空间和识别记忆以及感觉运动门控能力。虽然握力得以保留，但Ctrp10 KO雌性小鼠在转棒任务中表现出运动协调受损；然而，运动学习功能正常。平衡木行走和复杂跑轮任务进一步表明精细运动技能存在显著缺陷，且雌性KO小鼠表现出明显更显著的表现型。转录组学分析显示，CTRP10缺失改变了小脑和运动皮层中与突触组织、细胞信号传导、线粒体呼吸和运动行为相关的生物学通路。功能分析也表明KO小鼠运动皮层中线粒体呼吸能力降低。这些综合变化可能共同导致我们的KO动物出现运动功能缺陷。综上所述，我们的数据揭示了CTRP10的一个新型中枢功能，并为CTRP10对最佳粗大和精细运动功能是必需的提供了遗传学证据。

Keyword:

CTRP10

motor function

synaptic organization

mitochondrial respiration

fine motor skills

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期刊

Journal of Biological Chemistry

IF:

3.9

论文数:

11.2W

被引数:

28.3W

机构

medicine

学者数:

1.0W

论文数: 3.7K

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