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Dango: Predicting higher-order genetic interactions
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DOI：10.1016/j.cels.2026.101593.png)
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Abstract
En 中文
• DANGO is a hypergraph neural network for predicting higher-order genetic interactions • DANGO expands the yeast trigenic interaction landscape to over 400 million interactions • Protein embeddings and uncertainty scoring improve model interpretability • Predicted interactions improve genotype-to-phenotype mapping of yeast growth
Keywords:
DANGO
hypergraph neural network
higher-order genetic interactions
protein embeddings
genotype-to-phenotype mapping
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