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Deciphering tissue structure and function using spatial transcriptomics
DOI:10.1038/s42003-022-03175-5.png)
摘要
En 中文
The rapid development of spatial transcriptomics (ST) techniques has allowed the measurement of transcriptional levels across many genes together with the spatial positions of cells. This has led to an explosion of interest in computational methods and techniques for harnessing both spatial and transcriptional information in analysis of ST datasets. The wide diversity of approaches in aim, methodology and technology for ST provides great challenges in dissecting cellular functions in spatial contexts. Here, we synthesize and review the key problems in analysis of ST data and methods that are currently applied, while also expanding on open questions and areas of future development. Walker et al. review methods used to analyse spatial transcriptomics data and discuss open questions and areas of future development.
Keyword:
GENOME-WIDE EXPRESSION
GENE-EXPRESSION
SEQ
IDENTIFICATION
AI总结
对已上传原文的论文进行重点信息的提取,主要内容包括:简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
5.1
论文数:
1.1W
被引数:
3.2W
机构
引用论文
DSTG: deconvoluting spatial transcriptomics data through graph-based artificial intelligenceDSTG: 通过基于图形的人工智能对空间转录组数据进行反卷积
Identification of spatial expression trends in single-cell gene expression data单细胞基因表达数据中空间表达趋势的识别
NATURE METHODS
IF32.1
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexesCellPhoneDB: 从多亚基配体-受体复合物的联合表达推断细胞-细胞通讯
NATURE PROTOCOLS
IF16
In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus单细胞的原位转录谱分析揭示了小鼠海马中细胞的空间组织
NEURON
IF15

