Decoding Cardiac Maturation Program: Insights from RNA Splicing Regulation

doi:10.1007/s11886-025-02271-2

2025-09-20

PRE

Woan Ting Tay

Wang Yibin (Yibin Wang) *

DOI：10.1007/s11886-025-02271-2

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摘要

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新生后心肌细胞的成熟是哺乳动物心脏发育连续过程中的一个关键步骤，涉及形态学、分子和功能水平上的无数表型变化。尽管心脏成熟的表型特征已被充分表征，但调控这一成熟过程的分子机制仍定义不清。本文旨在探讨近期关于转录后调控如何协调胎儿至成年心肌细胞转变的研究发现，并强调其在心脏疾病和再生医学中的临床意义。心脏成熟的分子调控与心脏发育胚胎阶段的基因调控网络不同。RNA可变剪接及其产生的异构体转换事件是成熟过渡阶段转录后重编程的重要组成部分，通过RNA结合蛋白网络驱动功能优化。在胎儿至成年成熟过程中，心肌细胞在结构、生理、代谢活动和增殖能力方面发生显著变化。近期研究发现强调了转录后调控在此过程中的重要性，特别是RNA可变剪接和异构体转换。理解包括对胎儿至成年过渡有贡献的关键分子参与者的转录后调控机制，可以为心脏发育、疾病和再生医学提供新的概念框架。

Keyword:

Cardiac maturation

Cardiomyocyte

Post-transcriptional regulation

Alternative RNA splicing

Isoform switch

期刊

Current Cardiology Reports

IF:

3.3

论文数:

2.2K

被引数:

5.1K

机构

Duke-NUS Medical School

学者数:

436

论文数: 212

被引数: 9.2K

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