Decoding replication stress responses through post-translational modifications

doi:10.1038/s41589-025-02023-x

2025-10-07

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DOI：10.1038/s41589-025-02023-x

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DNA复制是一种基本的细胞过程，它确保在细胞分裂期间基因组的忠实复制。然而，这一过程经常受到各种内在和外在因素的挑战，这些因素可能阻碍复制叉进程并危及基因组完整性。为了应对这些挑战，细胞进化出了复杂的应激响应机制，包括复制检验点激活、损伤跨过DNA合成、重新引发和复制叉反转，所有这些对于维持基因组稳定性都至关重要。这些通路协调的核心是翻译后修饰（PTMs），它们动态调节参与复制应激响应的关键蛋白的稳定性、定位和活性。在本综述中，我们总结了协调细胞对复制应激反应的主要机制，并强调了关于组蛋白和非组蛋白PTM在基因毒性条件下精确协调调控复制叉动态作用的新见解。本综述探讨了翻译后修饰通过调控检验点信号、DNA修复和复制叉重塑来协调复制应激反应，从而在基因毒性条件下维持基因组稳定性。

Keyword:

Replication stress

Post-translational modifications

DNA replication

Genomic stability

Checkpoint signaling

期刊

Nature Chemical Biology

IF:

13.7

论文数:

4.8K

被引数:

3.3W

机构

Zhejiang Key Laboratory of Oral Biomedical

学者数:

论文数: 13

被引数: 0

Zhejiang University School of Medicine

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4.6K

论文数: 1.2K

被引数: 1

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