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Design, synthesis and anti-tumor activities of pyridine-benzamide containing dithiocarbamate moiety as EZH2 inhibitors
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DOI：10.1016/j.bmc.2025.118514.png)
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Abstract
En 中文
• These studies contribute modern and practical strategies to the development of more effective antitumor drugs. • This breakthrough has expanded the application prospects of dithiocarbamate compounds. • A series of pyridine-benzamide containing dithiocarbamate moiety derivatives were designed and synthesized. • Compound N16 potently inhibits EZH2 WT and Pfeiffer cell proliferation, showing greater efficacy than Tazemetostat.
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B
IF:
3
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1.7W
Citations:
2.7W
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