Determining the dark proteome

doi:10.1038/s41589-026-02320-z

2026-09-08

PRE

Maja Bencun

Etienne Boileau

Christoph Dieterich *

DOI：10.1038/s41589-026-02320-z

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人类基因组包含经典的蛋白质编码基因和大量的非经典编码区域，然而后者的翻译产物在很大程度上仍未被探索。现在，TransCODE联盟通过绘制人类非经典蛋白质组景观，为这一隐藏层提供了系统性的视角。

期刊

Nature Chemical Biology

IF:

13.7

论文数:

4.8K

被引数:

3.3W

机构

university of heidelberg

学者数:

450

论文数: 181

被引数: 0

引用论文

Świrski, M.I.; Tierney, J.A.S.; Albà, M.M.; Andreev, D.E.; Aspden, J.L.; Atkins, J.F.; Bassani-Sternberg, M.; Berry, M.J.; Biffo, S.; Boris-Lawrie, K.; et al. Translon: A Single Term for Translated Regions. Nat. Methods 2025, 22, 2002–2006. [Google Scholar] [CrossRef] [PubMed]Świrski, M.I.; Tierney, J.A.S.; Albà, M.M.; Andreev, D.E.; Aspden, J.L.; Atkins, J.F.; Bassani-Sternberg, M.; Berry, M.J.; Biffo, S.; Boris-Lawrie, K.; 等. Translon: 翻译区域的单一术语. Nat. Methods 2025, 22, 2002–2006. [Google Scholar] [CrossRef] [PubMed]

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