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Differences in Mouse and Human Nonmemory B Cell Pools
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DOI：10.4049/jimmunol.1300692.png)
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摘要
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Identifying cross-species similarities and differences in immune development and function is critical for maximizing the translational potential of animal models. Coexpression of CD21 and CD24 distinguishes transitional and mature B cell subsets in mice. In this study, we validate these markers for identifying analogous subsets in humans and use them to compare the nonmemory B cell pools in mice and humans, across tissues, and during fetal/neonatal and adult life. Among human CD19(+) IgM(+) B cells, the CD21/CD24 schema identifies distinct populations that correspond to transitional 1 (T1), transitional 2 (T2), follicular mature, and marginal zone subsets identified in mice. Markers specific to human B cell development validate the identity of marginal zone cells and the maturation status of human CD21/CD24 nonmemory B cell subsets. A comparison of the nonmemory B cell pools in bone marrow, blood, and spleen in mice and humans shows that transitional B cells comprise a much smaller fraction in adult humans than mice. T1 cells are a major contributor to the nonmemory B cell pool in mouse bone marrow, in which their frequency is more than twice that in humans. Conversely, in spleen, the T1:T2 ratio shows that T2 cells are proportionally similar to 8-fold higher in humans than in mice. Despite the relatively small contribution of transitional B cells to the human nonmemory pool, the number of naive follicular mature cells produced per transitional B cell is 3-to 6-fold higher across tissues than in mice. These data suggest differing dynamics or mechanisms produce the nonmemory B cell compartments in mice and humans.
Keyword:
SPLENIC MARGINAL ZONE
FUNCTIONALLY DISTINCT
LYMPHOCYTE SUBSETS
CUTTING EDGE
BONE-MARROW
BAFF
EXPRESSION
SURVIVAL
BLOOD
IDENTIFICATION
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期刊
IF:
3.4
论文数:
3.7W
被引数:
9.9W
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引用论文
B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals脾脏中的b细胞发育以不连续的步骤进行，并由b细胞受体衍生信号的质量决定OAAI
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