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Dilated cardiomyopathy
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DOI：10.1038/s41572-019-0084-1.png)
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Abstract
En 中文
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions (for example, hypertension and valvular heart disease) or coronary artery disease. Mutations in several genes can cause DCM, including genes encoding structural components of the sarcomere and desmosome. Nongenetic forms of DCM can result from different aetiologies, including inflammation of the myocardium due to an infection (mostlyviral); exposure to drugs, toxins or allergens; and systemic endocrine or autoimmune diseases. The heterogeneous aetiology and clinical presentation of DCM make a correct and timely diagnosis challenging. Echocardiography and other imaging techniques are required to assess ventricular dysfunction and adverse myocardial remodelling, and immunological and histological analyses of an endomyocardial biopsy sample are indicated when inflammation or infection is suspected. As DCM eventually leads to impaired contractility, standard approaches to prevent or treat heart failure are the first-line treatment for patients with DCM. Cardiac resynchronization therapy and implantable cardioverter-defibrillators may be required to prevent life-threatening arrhythmias. In addition, identifying the probable cause of DCM helps tailor specific therapies to improve prognosis. An improved aetiology-driven personalized approach to clinical care will benefit patients with DCM, as will new diagnostic tools, such as serum biomarkers, that enable early diagnosis and treatment.
Keywords:
HEPATITIS-C VIRUS
LEFT-VENTRICULAR FUNCTION
CHRONIC HEART-FAILURE
CARDIAC-RESYNCHRONIZATION THERAPY
CARDIOLOGY WORKING GROUP
FREE LIGHT-CHAINS
COXSACKIEVIRUS B3-INDUCED MYOCARDITIS
CONVERTING-ENZYME-INHIBITORS
INTERFERON-BETA TREATMENT
CORONARY-ARTERY-DISEASE
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