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Discovery and Characterization of YSA64, a RBM39 Degrader with In Vivo Efficacy and Potent Cellular Activity in Pediatric Ewing Sarcoma A673
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DOI：10.1016/j.ejmech.2026.118921.png)
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Abstract
En 中文
• A structurally distinct and selective RBM39 degrader, 41, was identified. • 41 exhibits potent activity in A673 cells derived from orphan Ewing sarcoma. • 41 demonstrates in vivo efficacy in an MV4-11 xenograft mouse model.
Keywords:
RBM39 degrader
Ewing sarcoma
A673 cells
in vivo efficacy
YSA64
Journal
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5.9
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1.7W
Citations:
6.0W
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