DNA replication timing influences gene expression level

doi:10.1083/jcb.201701061

2017-05-24

Carolin A. Müller

Conrad A. Nieduszynski *

DOI：10.1083/jcb.201701061

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摘要

En 中文

Eukaryotic genomes are replicated in a reproducible temporal order; however, the physiological significance is poorly understood. We compared replication timing in divergent yeast species and identified genomic features with conserved replication times. Histone genes were among the earliest replicating loci in all species. We specifically delayed the replication of HTA1-HTB1 and discovered that this halved the expression of these histone genes. Finally, we showed that histone and cell cycle genes in general are exempt from Rtt109-dependent dosage compensation, suggesting the existence of pathways excluding specific loci from dosage compensation mechanisms. Thus, we have uncovered one of the first physiological requirements for regulated replication time and demonstrated a direct link between replication timing and gene expression.

Keyword:

GENOME

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ORIGINS

CDC45

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对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Journal of Cell Biology

IF:

6.4

论文数:

1.2W

被引数:

5.7W

机构

university of oxford

学者数:

9.8W

论文数: 8.6W

被引数: 137

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