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Does Sequence Conservation Provide Evidence for Biological Function?
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DOI：10.1016/j.tim.2016.09.010.png)
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摘要
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Finding a signature of purifying selection in a gene is usually interpreted as evidence for the gene providing a function that is targeted by natural selection. This opinion offers a very different hypothesis: purifying selection may be due to removing harmful mutations from the population, that is, the gene and its encoded protein become harmful after a mutation occurred, possibly because the mutated protein interferes with the translation machinery, or because of toxicity of the misfolded protein. Finding a signature of purifying selection should not automatically be considered proof of the gene's selectable function.
Keyword:
HIGHLY EXPRESSED PROTEINS
GENETICAL EVOLUTION
GENES
WIDESPREAD
GENOMES
LEVEL
COST
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