.png){kind=icon}
返回
Drug repurposing for stroke intervention
.png){kind=icon}
PRE
AI
DOI：10.1016/j.drudis.2022.03.003.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Despite the availability of advanced interventions, stroke remains one of the most significant causes of mortality and morbidity worldwide. US Food and Drug Administration (FDA)-approved treatment options for stroke include tissue plasminogen activators (tPAs) and mechanical thrombectomy (MT). However, these are limited by a narrow therapeutic time window. Additionally, poststroke rehabilitation therapies can provide functional recovery but take a long time to show benefits. Drug repurposing could be a novel approach to broaden treatment options in this scenario. In this review, we summarize marketed drugs that could be repurposed based on their safety and efficacy data. We also briefly discuss their mechanisms of action and provide a list of repurposed drugs under trials for ischemic stroke therapy.
Keyword:
Ischemic stroke
Drug repurposing
Conventional therapy
Recombinant-tissue plasminogen activator
Mechanical thrombectomy
Drug development
期刊
IF:
7.5
论文数:
6.4K
被引数:
2.3W
机构
引用论文
Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.png)
FOOD CHEMISTRY
FOOD CHEMISTRYIF9.8
PREAI
分享收藏Relationships Between Adolescent Psychiatric Diagnoses, Music Preferences, and Drug Preferences
PREAI
分享收藏Normal-incidence pulsed-laser deposition: better method for fabrication of multilayer structures
PREAI
分享收藏The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy药物再利用联合再灌注治疗缺血性卒中的潜力: 血管内血栓切除术的补充策略LIFE SCIENCES
LIFE SCIENCESIF5.1
PREAI
分享收藏
查看更多内容