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Dual-Capped Helical Interface Mimics
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DOI：10.1021/jacs.3c11717.png)
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摘要
En 中文
Disruption of protein-protein interactions is medicinally important. Interface helices may be mimicked in helical probes featuring enhanced rigidities, binding to protein targets, stabilities in serum, and cell uptake. This form of mimicry is dominated by stapling between side chains of helical residues: there has been less progress on helical N-caps, and there were no generalizable C-caps. Conversely, in natural proteins, helicities are stabilized and terminated by C- and N-caps but not staples. Bicyclic caps previously introduced by us enable interface helical mimicry featuring rigid synthetic caps at both termini in this work. An unambiguously helical dual-capped system proved to be conformationally stable, binding cyclins A and E, and showed impressive cellular uptake. In addition, the dual-capped mimic was completely resistant to proteolysis in serum over an extended period when compared with gold standard hydrocarbon-stapled controls. Dual-capped peptidomimetics are a new, generalizable paradigm for helical interface probe design.
Keyword:
PROTEIN-PROTEIN INTERACTIONS
POLYPEPTIDE MODEL COMPOUNDS
SECONDARY-STRUCTURE
STAPLED PEPTIDES
AMINO-ACIDS
CHAIN
DESIGN
NUCLEATION
INHIBITORS
STABILITY
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期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
机构
引用论文
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