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Electroreductive Olefin-Ketone Coupling
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DOI：10.1021/jacs.0c11214.png)
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摘要
En 中文
A user-friendly approach is presented to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when adding to simple unactivated olefins to accomplish the same overall transformation. The scope of this coupling is broad as enabled using an electrochemical approach, and the reaction is scalable, chemoselective, and requires no precaution to exclude air or water. Multiple applications demonstrate the simplifying nature of the reaction on multistep synthesis, and mechanistic studies point to an intuitive mechanism reminiscent of other chemical reductants such as SmI2 (which cannot accomplish the same reaction).
Keyword:
PHOTOREDUCTIVE CYCLIZATION
REDUCTIVE CYCLIZATION
ELECTROORGANIC CHEMISTRY
TERTIARY ALCOHOLS
CATALYZED ADDITION
CARBONYL-COMPOUNDS
ALPHA-OLEFINS
SOLID-PHASE
REAGENTS
TITANIUM
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期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
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