Engineering Cell Surface Function with DNA Origami

Ehsan Akbari

doi:10.1002/adma.201703632

2017-10-13

104

DOI：10.1002/adma.201703632

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摘要

En 中文

A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.

Keyword:

cell surface engineering

DNA nanotechnology

DNA origami

intercellular adhesion

membrane functionalization

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期刊

Advanced Materials

IF:

26.8

论文数:

3.5W

被引数:

46.0W

机构

University System of Ohio

学者数:

15.5W

论文数: 13.0W

被引数: 200

Ohio State University

学者数:

571

论文数: 276

被引数: 0

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