.png){kind=icon}
返回
Evolutionary adaptations to new environments generally reverse plastic phenotypic changes
.png){kind=icon}
OA
AI
DOI：10.1038/s41467-017-02724-5.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Organismal adaptation to a new environment may start with plastic phenotypic changes followed by genetic changes, but whether the plastic changes are stepping stones to genetic adaptation is debated. Here we address this question by investigating gene expression and metabolic flux changes in the two-phase adaptation process using transcriptomic data from multiple experimental evolution studies and computational metabolic network analysis, respectively. We discover that genetic changes more frequently reverse than reinforce plastic phenotypic changes in virtually every adaptation. Metabolic network analysis reveals that, even in the presence of plasticity, organismal fitness drops after environmental shifts, but largely recovers through subsequent evolution. Such fitness trajectories explain why plastic phenotypic changes are genetically compensated rather than strengthened. In conclusion, although phenotypic plasticity may serve as an emergency response to a new environment that is necessary for survival, it does not generally facilitate genetic adaptation by bringing the organismal phenotype closer to the new optimum.
Keyword:
CONSTRAINT-BASED MODELS
ESCHERICHIA-COLI
GENE-EXPRESSION
ADAPTIVE EVOLUTION
GROWTH
EPISTASIS
STRAINS
CELLS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
机构
引用论文
Why Is the Correlation between Gene Importance and Gene Evolutionary Rate So Weak?.png)
PLOS GENETICSOAAI
PLOS GENETICSIF3.7
OAAI分享收藏PREDICTION OF THE OUTCOME OF TRANSPLANTATION IN MAN BY PLATELET ADHERENCE IN DONOR LIVER ALLOGRAFTS同种异体供肝中血小板粘附预测人移植的结果OAAI
OAAI分享收藏The influence of phenotypic modifications on evolution: the Baldwin effect and modern perspectivesOIKOS
OIKOSIF3
PREAI
分享收藏Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations大肠杆菌到42 °C的进化和随后的基因工程揭示了适应机制和新的突变OAAI
OAAI分享收藏
查看更多内容