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ExonSuite: Algorithmically optimizing alternative gene splicing for the PUF proteins
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DOI：10.1016/j.compbiomed.2013.05.014.png)
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摘要
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The stability of mRNA and its translation is a vital process necessary for proper protein production. The specificity of the regulation is controlled by specific RNA motifs and regulatory proteins. Pumilio/fem-3 mRNA-binding factor (PUF) proteins are usually used in regulating mRNA stability as well as translation. Here, we optimized a PUF protein target finder program to understand the natural diversity of RNA recognition by this family of proteins. ExonSuite is available to compile and run at https://github.com/dilanustek/ExonSuite. (C) 2013 Elsevier Ltd. All rights reserved.
Keyword:
Software
Exon
PUF proteins
Gene splicing
Data mining
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