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ExpressVis: a biologist-oriented interactive web server for exploring multi-omics data

delete2022-05-25
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OA
AI
X
Xian Liu
K
Kaikun Xu
陶鑫 封面图
陶鑫 (Xin Tao)
R
Rong‐Hua Yin
G
Guangming Ren
于淼 封面图
于淼 (Miao Yu)
C
Chang‐Yan Li
陈
陈灰 (Hui Chen)
K
Ke Zhao
S
Shensi Xiang
高慧颖 封面图
高慧颖 (Huiying Gao)
X
Xiaochen Bo *
C
Cheng Chang *
X
Xiaoming Yang *
DOI:10.1093/nar/gkac399delete
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摘要

摘要

En 中文
In the era of life-omics, huge amounts of multi-omics data have been generated and widely used in biomedical research. It is challenging for biologists with limited programming skills to obtain biological insights from multi-omics data. Thus, a biologist-oriented platform containing visualization functions is needed to make complex omics data digestible. Here, we propose an easy-to-use, interactive web server named ExpressVis. In ExpressVis, users can prepare datasets; perform differential expression analysis, clustering analysis, and survival analysis; and integrate expression data with protein-protein interaction networks and pathway maps. These analyses are organized into six modules. Users can use each module independently or use several modules interactively. ExpressVis displays analysis results in interactive figures and tables, and provides comprehensive interactive operations in each figure and table, between figures or tables in each module, and among different modules. It is freely accessible at https://omicsmining.ncpsb.org.en/ExpressVis and does not require login. To test the performance of ExpressVis for multi-omics studies of clinical cohorts, we re-analyzed a published hepatocellular carcinoma dataset and reproduced their main findings, suggesting that ExpressVis is convenient enough to analyze multi-omics data. Based on its complete analysis processes and unique interactive opera- tions, ExpressVis provides an easy-to-use solution for exploring multi-omics data. [GRAPHICS] .
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期刊

Nucleic Acids Research 封面图
Nucleic Acids Research
IF:
13.1
论文数:
3.6W
被引数:
29.4W

机构

A
academy of military medical sciences - china
学者数:
8.9K
论文数: 4.2K
被引数: 323
C
chongqing university of posts & telecommunications
学者数:
0
论文数: 139
被引数: 0
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