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Extracellular matrix-based cancer targeting
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DOI：10.1016/j.molmed.2021.07.009.png)
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摘要
En 中文
Tumor extracellular matrix (ECM) operates in a coordinated mode with cancer and stroma cells to evoke the multistep process of metastatic potential. The remodeled tumor-associated matrix provides a point for direct or complemen-tary therapeutic targeting. Here, we cover and critically address the importance of ECM networks and their macromolecules in cancer. We focus on the roles of key structural and functional ECM components, and their degradation enzymes and extracellular vesicles, aiming at improving our understanding of the mecha-nisms contributing to tumor initiation, growth, and dissemination, and discuss potential new approaches for ECM-based therapeutic targeting and diagnosis.
Keyword:
ESTROGEN-RECEPTOR BETA
HEPARAN-SULFATE
TUMOR-GROWTH
CELLS
PROTEOGLYCANS
REGULATORS
EXOSOMES
DOMAIN
HEAD
PROGRESSION
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2.6K
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