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GENCODE 2021
DOI:10.1093/nar/gkaa1087.png)
摘要
En 中文
The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make use of primary data and bioinformatic tools and analysis generated both within the consortium and externally to support the creation of transcript structures and the determination of their function. Here, we present improvements to our annotation infrastructure, bioinformatics tools, and analysis, and the advances they support in the annotation of the human and mouse genomes including: the completion of first pass manual annotation for the mouse reference genome; targeted improvements to the annotation of genes associated with SARS-CoV-2 infection; collaborative projects to achieve convergence across reference annotation databases for the annotation of human and mouse protein-coding genes; and the first GENCODE manually supervised automated annotation of lncRNAs.
Keyword:
LONG NONCODING RNAS
ANNOTATION
DATABASE
ATLAS
AI总结
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期刊
IF:
13.1
论文数:
3.6W
被引数:
29.0W
机构
引用论文
GENCODE: The reference human genome annotation for The ENCODE ProjectGENCODE: ENCODE项目的参考人类基因组注释
GENOME RESEARCH
IF5.5
CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise
GENOME BIOLOGY
IF9.4
High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing
NATURE GENETICS
IF31.8


