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Genetic associations with educational fields

delete2025-11-04
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OA
AI
R
Rosa Cheesman *
V
Ville Anapaz
S
Sjoerd van Alten
A
Abdel Abdellaoui
R
Ralph P. O. Porneso
J
Joakim Coleman Ebeltoft
Z
Ziada Ayorech
P
Perline Demange
E
Espen Moen Eilertsen
A
Agnes Fauske
A
Alexandra Havdahl
H
Hannu Lahtinen
T
Torkild Hovde Lyngstad
Q
Qi Qin
A
Andrea Ganna
E
Eivind Ystrøm
DOI：10.1038/s41588-025-02391-zdelete
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摘要

摘要

En 中文
教育领域的选择塑造了职业生涯、幸福感和社会技能分布，但遗传因素对人们所学科目的影响仍知之甚少。本研究表明，通过来自芬兰、挪威和荷兰463,134名个体（有效样本量在40,072至317,209之间）的全基因组关联研究（GWASs），遗传因素与教育领域专业化相关。我们鉴定出17个独立的全基因组显著变异，与10个教育领域中的7个相关，平均遗传力为7%。遗传信号特指领域选择而非教育水平，在控制受教育年限和混杂因素后仍持续存在。通过考察专业化的遗传聚类，我们发现了两个关键维度：技术与社会、实践与抽象。我们对这些成分进行GWASs，并证明其与人格、行为和社会经济地位存在独特的遗传相关性。我们的发现表明，基因组学研究可以阐明“横向”分层，揭示有关职业兴趣和社会分层的新见解，这些超出了传统成就指标。对10个教育领域的全基因组分析鉴定出17个相关基因座。对专业化间遗传聚类的分析识别出两个关键维度，这些维度与人格特质、行为特质和社会经济地位存在遗传重叠。
Keyword:
educational fields
genome-wide association studies
heritability
vocational interests
genetic clustering
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期刊

Nature Genetics 封面图
Nature Genetics
IF:
29
论文数:
738
被引数:
241

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U
university of helsinki
学者数:
4.1W
论文数: 3.6W
被引数: 51
V
Vrije Universiteit Amsterdam
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4.2W
论文数: 3.7W
被引数: 3.7W
U
university of amsterdam
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6.0W
论文数: 5.1W
被引数: 94
U
university of oslo
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4.2W
论文数: 3.5W
被引数: 53
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