Harnessing off-target effects

Gaye Saginc

doi:10.1038/nchembio.2519

2017-11-21

PRE

Gaye Saginc

Franziska Voellmy

Rune Linding *

DOI：10.1038/nchembio.2519

原文链接

原文求助

摘要

En 中文

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.

Keyword:

CHEMOTHERAPY

CERITINIB

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Nature Chemical Biology

IF:

13.7

论文数:

4.8K

被引数:

3.3W

机构

University of Copenhagen

学者数:

7.6W

论文数: 6.6W

被引数: 86

引用论文

Timeline - Chemotherapy and the war on cancer 时间表-化疗和对癌症的战争

NATURE REVIEWS CANCER

IF66.8

2005-01-01

2.0K

PREAI

Chabner, BA; Roberts, TG

SIMULATION OF DEEP BED DRYING OF HAZELNUTS

Drying Technology

IF0

1998-01-01

PREAI

A. López; M.T. Piqué; A. Romero

Recent advances of cocktail chemotherapy by combination drug delivery systems 联合给药系统鸡尾酒化疗的研究进展

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2016-03-01

538

OAAI

Hu, Quanyin; Sun, Wujin; Wang, Chao; Gu, Zhen

The influence of drug-like concepts on decision-making in medicinal chemistry

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2007-11-01

2.0K

PREAI

Leeson, Paul D.; Springthorpe, Brian

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

NATURE MEDICINE

IF50

2014-08-31

260

OAAI

Lovly, Christine M.; McDonald, Nerina T.; Chen, Heidi; Ortiz-Cuaran, Sandra; Heukamp, Lukas C.; Yan, Yingjun; Florin, Alexandra; Ozretic, Luka; Lim, Diana; Wang, Lu; Chen, Zhao; Chen, Xi; Lu, Pengcheng; Paik, Paul K.; Shen, Ronglai; Jin, Hailing; Buettner, Reinhard; Ansen, Sascha; Perner, Sven; Brockmann, Michael; Bos, Marc; Wolf, Juergen; Gardizi, Masyar; Wright, Gavin M.; Solomon, Benjamin; Russell, Prudence A.; Rogers, Toni-Maree; Suehara, Yoshiyuki; Red-Brewer, Monica; Tieu, Rudy; de Stanchina, Elisa; Wang, Qingguo; Zhao, Zhongming; Johnson, David H.; Horn, Leora; Wong, Kwok-Kin; Thomas, Roman K.; Ladanyi, Marc; Pao, William

SWIFT trial of delayed elective intervention v conservative treatment after thrombolysis with anistreplase in acute myocardial infarction. SWIFT (Should We Intervene Following Thrombolysis?) Trial Study Group.

BMJ

IF0

1991-03-09

OAAI

Polypharmacology-based ceritinib repurposing using integrated functional proteomics

NATURE CHEMICAL BIOLOGY

IF13.7

2017-10-09

OAAI

Kuenzi, Brent M.; Rix, Lily L. Remsing; Stewart, Paul A.; Fang, Bin; Kinose, Fumi; Bryant, Annamarie T.; Boyle, Theresa A.; Koomen, John M.; Haura, Eric B.; Rix, Uwe

Drugging the 'undruggable' cancer targets 给 “不可下药” 的癌症目标下药

NATURE REVIEWS CANCER

IF66.8

2017-06-23

673

OAAI

Dang, Chi V.; Reddy, E. Premkumar; Shokat, Kevan M.; Soucek, Laura

Network pharmacology: the next paradigm in drug discovery 网络药理学: 药物发现的下一个范式

NATURE CHEMICAL BIOLOGY

IF13.7

2008-10-20

3.4K