Hepatic steatosis in adults on CFTR modulators is commonly associated with cardiometabolic criteria consistent with metabolic dysfunction-associated steatotic liver disease

2026-07-01

PRE

Sofia Manioudaki

Larisa Vasilieva

Eleni Geladari

Iliana Mani

Vassilios Sevastianos

Filia Diamantea

Αlexandra Alexopoulou *

DOI：10.1016/j.jcf.2026.06.008

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• In pwCF receiving treatment, BMI increased significantly during a 2-year follow-up. • Increased body weight is an independent predictor of hepatic steatosis. • Weight gain did not necessarily lead to hepatic steatosis. • Liver stiffness improves in pwCF receiving CFTR modulators. • Most pwCF with HS exhibit cardiometabolic features consistent with MASLD.

Hepatic steatosis in adults on CFTR modulators is commonly associated with cardiometabolic criteria consistent with metabolic dysfunction-associated steatotic liver disease

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