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High-throughput behavioral analysis in C. elegans
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DOI：10.1038/NMETH.1625.png)
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We designed a real-time computer vision system, the Multi-Worm Tracker (MWT), which can simultaneously quantify the behavior of dozens of Caenorhabditis elegans on a Petri plate at video rates. We examined three traditional behavioral paradigms using this system: spontaneous movement on food, where the behavior changes over tens of minutes; chemotaxis, where turning events must be detected accurately to determine strategy; and habituation of response to tap, where the response is stochastic and changes over time. In each case, manual analysis or automated single-worm tracking would be tedious and time-consuming, but the MWT system allowed rapid quantification of behavior with minimal human effort. Thus, this system will enable large-scale forward and reverse genetic screens for complex behaviors.
Keyword:
NEMATODE CAENORHABDITIS-ELEGANS
SENSORY CILIA
PLASTICITY
TRACKING
SYSTEM
CHEMOTAXIS
MODEL
期刊
IF:
32.1
论文数:
7.2K
被引数:
12.7W
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A putative cyclic nucleotide-gated channel is required for sensory development and function in C-elegans.png)
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