.png){kind=icon}
返回
Hippocampal Attractor Dynamics Predict Memory-Based Decision Making
.png){kind=icon}
OA
AI
DOI：10.1016/j.cub.2016.04.063.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Memories are thought to be retrieved by attractor dynamics if a given input is sufficiently similar to a stored attractor state [1-5]. The hippocampus, a region crucial for spatial navigation [6-12] and episodic memory [13-18], has been associated with attractorbased computations [5, 9], receiving support from the way rodent place cells ``remap'' nonlinearly between spatial representations [19-22]. In humans, nonlinear response patterns have been reported in perceptual categorization tasks [23-25]; however, it remains elusive whether human memory retrieval is driven by attractor dynamics and what neural mechanisms might underpin them. To test this, we used a virtual reality [7, 11, 26-28] task where participants learned object-location associations within two distinct virtual reality environments. Participants were subsequently exposed to four novel intermediate environments, generated by linearly morphing the background landscapes of the familiar environments, while tracking fMRI activity. We show that linear changes in environmental context cause linear changes in activity patterns in sensory cortex but cause dynamic, nonlinear changes in both hippocampal activity pattern and remembered locations. Furthermore, the sigmoidal response in the hippocampus scaled with the strength of the sigmoidal pattern in spatial memory. These results indicate that mnemonic decisions in an ambiguous novel context relate to putative attractor dynamics in the hippocampus, which support the dynamic remapping of memories.
Keyword:
MEDIAL TEMPORAL-LOBE
COMPLEMENTARY-LEARNING-SYSTEMS
VOXEL PATTERN-ANALYSIS
SPATIAL NAVIGATION
RECOGNITION MEMORY
REAL-WORLD
REPRESENTATIONS
NETWORKS
CONTEXT
INTEGRATION
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7.5
论文数:
2.2W
被引数:
7.8W
机构
引用论文
Preference by Association: How Memory Mechanisms in the Hippocampus Bias Decisions.png)
SCIENCE
SCIENCEIF45.8
PREAI
分享收藏Progressive Transformation of Hippocampal Neuronal Representations in Morphed EnvironmentsNEURONOAAI
NEURONIF15
OAAI分享收藏Constructing Rh–Rh3+ modified Ta2O5@TaON@Ta3N5 with special double n–n mutant heterojunctions for enhanced photocatalytic H2-evolutionRSC AdvancesOAAI
RSC AdvancesIF0
OAAI分享收藏WHY THERE ARE COMPLEMENTARY LEARNING-SYSTEMS IN THE HIPPOCAMPUS AND NEOCORTEX - INSIGHTS FROM THE SUCCESSES AND FAILURES OF CONNECTIONIST MODELS OF LEARNING AND MEMORY为什么在海马和新大脑皮层中存在互补的学习系统-来自学习和记忆的连接主义模型的成功和失败的见解PSYCHOLOGICAL REVIEW
PSYCHOLOGICAL REVIEWIF5.8
PREAI
分享收藏
查看更多内容