Hitting the hotspots

Christopher B. Marshall

doi:10.1038/s41589-022-01000-y

Hitting the hotspots

2022-03-21

2

PRE

AI

C

Christopher B. Marshall

M

Mitsuhiko Ikura *

DOI：10.1038/s41589-022-01000-y

原文链接

原文求助

摘要

En 中文

Despite well-established tumorigenic roles of KRAS mutants, targeting their smooth surfaces was a challenge, which was overcome through the development of G12C-specific covalent inhibitors. A new study shows that optimizing non-covalent interactions with a cryptic pocket produces remarkable potency for another hotspot mutation.

Hitting the hotspots

摘要

期刊

机构