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M

Mitsuhiko Ikura

university health network
H指数:94
被引数:3.7万

个人简介

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教育背景

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工作经历

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荣誉奖项

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CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

CD33和clusterin通过生物物理和遗传途径相互作用以调节阿尔茨海默病风险

Nature Communications
IF15.7
2026-07-170
OAAI
Roger B. Dodd; Masahiro Enomoto; Ye Zhou; Kanayo Satoh; Yalun Zhang; Fusheng Chen; Beatrice Acheson; Deniz Ghaffari; Elizabeth Sayn-Wittgenstein; Jamie J. Manning; George V. Dukas; Ronak Patel; Alondra Schweizer Burguete; Mason J. Kralovec; Mamunur Rashid; Jennifer L. Hall; Kirstin A. Tamucci; Zena Chatila; Minghua Liu; Annie J. Lee; Badri N. Vardarajan; Mariko F. Taga; Sirkku Pollari; Alon Rabinovitch; Cory D. Rillahan; Andrey A. Bobkov; Eduard Sergienko; William Meadows; Seema Qamar; Suzanne J. Randle; Christopher M. Johnson; Jean Sevalle; Jennifer Griffin; Christopher Bohm; Mitsuhiko Ikura; Xunde Xian; Joachim Herz; Megan A. Kelly; Jennifer West; Sandeep Satapathy; Mark R. Wilson; Jonathan A. Javitch; Paul E. Fraser; David A. Bennett; Philip L. De Jager; Zvi Fishelson; Dan Frenkel; Wesley B. Asher; Elizabeth M. Bradshaw; Peter St George-Hyslop
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors

DIRAS3衍生的环状肽破坏KRAS-RAF相互作用和KRAS纳米聚集，抑制KRAS驱动的胰腺和卵巢肿瘤

iScience
IF4.1
2025-10-040
OAAI
Joshua P. Gray; Gamze Bildik; Ha-Neul Kim; Margie N. Sutton; Jing Wang; Amarachi O. Osuji; Nefeli Batistatou; Hailing Yang; Weiqun Mao; Zhi Tan; Geneviève M.C. Gasmi-Seabrook; Junchen Liu; John F. Hancock; Christopher B. Marshall; Joshua A. Kritzer; Mitsuhiko Ikura; Robert C. Bast; Steven W. Millward; Zhen Lu
Regulation of GTPase function by autophosphorylation
MOLECULAR CELL
IF16.6
2022-03-0111
OA
Johnson, Christian W.; Seo, Hyuk-Soo; Terrell, Elizabeth M.; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M. C.; Geffken, Ezekiel A.; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A.; Liu, Andrea; Mattos, Carla; Marshall, Christopher B.; Ikura, Mitsuhiko; Morrison, Deborah K.; Dhe-Paganon, Sirano; Haigis, Kevin M.
Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin

力诱导的 α-catenin构象变化独立于vinculin稳定血管连接

JOURNAL OF CELL SCIENCE
IF3.6
2021-12-2210
OAAI
Duong, Cao Nguyen; Brueckner, Randy; Schmitt, Martina; Nottebaum, Astrid F.; Braun, Laura J.; Zu Brickwedde, Marika Meyer; Ipe, Ute; Vom Bruch, Hermann; Schoeler, Hans R.; Trapani, Giuseppe; Trappmann, Britta; Ebrahimkutty, Mirsana P.; Huveneers, Stephan; de Rooij, Johan; Ishiyama, Noboru; Ikura, Mitsuhiko; Vestweber, Dietmar
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
NATURE COMMUNICATIONS
IF15.7
2021-11-0130
OAAI
Gebregiworgis, Teklab; Kano, Yoshihito; St-Germain, Jonathan; Radulovich, Nikolina; Udaskin, Molly L.; Mentes, Ahmet; Huang, Richard; Poon, Betty P. K.; He, Wenguang; Valencia-Sama, Ivette; Robinson, Claire M.; Huestis, Melissa; Miao, Jinmin; Yeh, Jen Jen; Zhang, Zhong-Yin; Irwin, Meredith S.; Lee, Jeffrey E.; Tsao, Ming-Sound; Raught, Brian; Marshall, Christopher B.; Ohh, Michael; Ikura, Mitsuhiko
The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis
JOURNAL OF CELL SCIENCE
IF3.6
2021-02-104
OA
Burgos, Miguel; Philippe, Reginald; Antigny, Fabrice; Buscaglia, Paul; Masson, Emmanuelle; Mukherjee, Sreya; Dubar, Pauline; Le Marechal, Cedric; Campeotto, Florence; Lebonvallet, Nicolas; Frieden, Maud; Llopis, Juan; Domingo, Beatriz; Stathopulos, Peter B.; Ikura, Mitsuhiko; Brooks, Wesley; Guida, Wayne; Chen, Jian-Min; Ferec, Claude; Capiod, Thierry; Mignen, Olivier
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

通过改变开关I和II构象使KRAS停止gtp酶循环的酪氨酰磷酸化

NATURE COMMUNICATIONS
IF15.7
2019-01-1582
OAAI
Kano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher B.; Radulovich, Nikolina; Poon, Betty P. K.; St-Germain, Jonathan; Cook, Jonathan D.; Valencia-Sama, Ivette; Grant, Benjamin M. M.; Herrera, Silvia Gabriela; Miao, Jinmin; Raught, Brian; Irwin, Meredith S.; Lee, Jeffrey E.; Yeh, Jen Jen; Zhang, Zhong-Yin; Tsao, Ming-Sound; Ikura, Mitsuhiko; Ohh, Michael

研究方向

暂未获取到该数据
C
Christopher B. Marshall
H 指数:38论文数:95被引数:3,984
P
Peter B. Stathopulos
H 指数:40论文数:164被引数:8,728
G
Geneviève M. C. Gasmi-Seabrook
H 指数:18论文数:48被引数:1,495
N
Noboru Ishiyama
H 指数:29论文数:87被引数:3,205
J
James B. Ames
H 指数:45论文数:197被引数:7,255
M
Matthew J. Smith
H 指数:31论文数:103被引数:4,004
T
Tapas K. Mal
H 指数:22论文数:59被引数:2,307
T
Teklab Gebregiworgis
H 指数:16论文数:44被引数:1,810
M
Masahiro Enomoto
H 指数:30论文数:159被引数:2,852
R
Robert Rottapel
H 指数:61论文数:311被引数:1.1万