Human neuron subtype programming via single-cell transcriptome-coupled patterning screens

doi:10.1126/science.adn6121

2025-07-10

PRE

Ann-Sophie Helene Kroell

DOI：10.1126/science.adn6121

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利用人类诱导多能干细胞生成诱导神经元已被广泛应用于神经科学研究的广泛领域，从疾病建模到药物筛选。然而，复制人类神经元巨大的异质性具有挑战性。Lin等人对480种形态发生因子组合进行了系统筛选，并结合两种不同转录因子之一的过表达，生成了一组诱导神经元，并采用单细胞RNA测序进行连续分析。作者识别了广泛的神经元亚型，并将其映射到神经管发育的前-后轴和背-腹轴上。研究结果为人类神经元工程提供了宝贵的资源。——Mattia Maroso

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Science

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45.8

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1.4W

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78.6W

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Department of Biosystems Science and Engineering

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论文数: 34

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学者数:

271

论文数: 72

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